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Citation
Kayashima, Y., Yamanashi, K., Sato, A., Kumazawa, S., Yamakawa-Kobayashi, K. (2012). Freeze-Dried Royal Jelly Maintains Its Developmental and Physiological Bioactivity in Drosophila melanogaster.  Biosci. Biotechnol. Biochem. 76(11): 2107--2111.
FlyBase ID
FBrf0220015
Publication Type
Research paper
Abstract

Royal jelly (RJ), a honeybee-derived product, has been found to possess developmental and physiological bioactivity in the fruit fly, Drosophila melanogaster, but little is known about the in vivo bioactivity of freeze-dried RJ (FDRJ) powder, which is another form of RJ processed for human use. To address this, we used Drosophila as a model animal to examine the effects of FDRJ in multicellular organisms. When flies were reared on food supplemented with FDRJ, the developmental time from larva to adult was shortened, the adult male lifespan was prolonged, and female fecundity was increased without any significant morphological alterations. Moreover, the expression of dilp5, an insulin-like peptide, its receptor InR, and the nutrient sensing molecule TOR, the target of rapamycin, was significantly increased in FDRJ-fed female flies as compared with ones reared on standard and on protein-enriched food. These findings suggest that like RJ, FDRJ maintains its bioactivity even after processing from RJ, what is expected to have bioactivity for multicellular organisms, including humans.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biosci. Biotechnol. Biochem.
    Title
    Bioscience, biotechnology, and biochemistry
    Publication Year
    1992-
    ISBN/ISSN
    0916-8451
    Data From Reference
    Genes (3)