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Citation
Ambegaonkar, A.A., Pan, G., Mani, M., Feng, Y., Irvine, K.D. (2012). Propagation of Dachsous-Fat planar cell polarity.  Curr. Biol. 22(14): 1302--1308.
FlyBase ID
FBrf0220288
Publication Type
Research paper
Abstract

The Fat pathway controls both planar cell polarity (PCP) and organ growth. Fat signaling is regulated by the graded expression of the Fat ligand Dachsous (Ds) and the cadherin-domain kinase Four-jointed (Fj). The vectors of these gradients influence PCP, whereas their slope can influence growth. The Fj and Ds gradients direct the polarized membrane localization of the myosin Dachs, which is a crucial downstream component of Fat signaling. Here we show that repolarization of Dachs by differential expression of Fj or Ds can propagate through the wing disc, which indicates that Fj and Ds gradients can be measured over long range. Through characterization of tagged genomic constructs, we show that Ds and Fat are themselves partially polarized along the endogenous Fj and Ds gradients, providing a mechanism for propagation of PCP within the Fat pathway. We also identify a biochemical mechanism that might contribute to this polarization by showing that Ds is subject to endoproteolytic cleavage and that the relative levels of Ds isoforms are modulated by Fat.

PubMed ID
PubMed Central ID
PMC3418676 (PMC) (EuropePMC)
Related Publication(s)
Supplementary material
Note

Cell Polarity: Overdosing on PCPs.
Blair, 2012, Curr. Biol. 22(14): R567--R569 [FBrf0219038]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Biol.
    Title
    Current Biology
    Publication Year
    1991-
    ISBN/ISSN
    0960-9822
    Data From Reference