Open Close
Reference
Citation
Djiane, A., Krejci, A., Bernard, F., Fexova, S., Millen, K., Bray, S.J. (2013). Dissecting the mechanisms of Notch induced hyperplasia.  EMBO J. 32(1): 60--71.
FlyBase ID
FBrf0220483
Publication Type
Research paper
Abstract
The outcome of the Notch pathway on proliferation depends on cellular context, being growth promotion in some, including several cancers, and growth inhibition in others. Such disparate outcomes are evident in Drosophila wing discs, where Notch overactivation causes hyperplasia despite having localized inhibitory effects on proliferation. To understand the underlying mechanisms, we have used genomic strategies to identify the Notch-CSL target genes directly activated during wing disc hyperplasia. Among them were genes involved in both autonomous and non-autonomous regulation of proliferation, growth and cell death, providing molecular explanations for many characteristics of Notch induced wing disc hyperplasia previously reported. The Notch targets exhibit different response patterns, which are shaped by both positive and negative feed-forward regulation between the Notch targets themselves. We propose, therefore, that both the characteristics of the direct Notch targets and their cross-regulatory relationships are important in coordinating the pattern of hyperplasia.
PubMed ID
PubMed Central ID
PMC3545308 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase
UAS-GFP:Su(H).
Reynolds and Bray, 2014.4.15, UAS-GFP:Su(H). [FBrf0224694]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO J.
    Title
    The EMBO Journal
    Publication Year
    1982-
    ISBN/ISSN
    0261-4189
    Data From Reference
    Aberrations (25)
    Alleles (64)
    Genes (42)
    Natural transposons (1)
    Insertions (9)
    Experimental Tools (1)
    Transgenic Constructs (54)