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Citation
Wang, L., Chiang, H.C., Wu, W., Liang, B., Xie, Z., Yao, X., Ma, W., Du, S., Zhong, Y. (2012). Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss.  Proc. Natl. Acad. Sci. U.S.A. 109(41): 16743--16748.
FlyBase ID
FBrf0220501
Publication Type
Research paper
Abstract

Current understanding of amyloid-β (Aβ) metabolism and toxicity provides an extensive list of potential targets for developing drugs for treating Alzheimer's disease. We took two independent approaches, including synaptic-plasticity-based analysis and behavioral screening of synthetic compounds, for identifying single compounds that are capable of rescuing the Aβ-induced memory loss in both transgenic fruit fly and transgenic mouse models. Two clinically available drugs and three synthetic compounds not only showed positive effects in behavioral tests but also antagonized the Aβ oligomers-induced activation of the epidermal growth factor receptor (EGFR). Such surprising converging outcomes from two parallel approaches lead us to conclude that EGFR is a preferred target for treating Aβ-induced memory loss.

PubMed ID
PubMed Central ID
PMC3478595 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (4)
    Genes (4)
    Human Disease Models (1)
    Transgenic Constructs (4)