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Citation
Neckameyer, W.S., Argue, K.J. (2013). Comparative approaches to the study of physiology: Drosophila as a physiological tool.  Am. J. Physiol. R., Regul. Integr. Comp. Physiol. 304(3): R177--R188.
FlyBase ID
FBrf0220702
Publication Type
Review
Abstract

Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, the way in which pain circuits are integrated to elicit responses from sensation, as well as the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.

PubMed ID
PubMed Central ID
PMC3567352 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Am. J. Physiol. R., Regul. Integr. Comp. Physiol.
    Title
    American Journal of Physiology
    Publication Year
    1977-
    ISBN/ISSN
    0363-6119 1522-1490
    Data From Reference