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Citation
Katoh, T., Tiemeyer, M. (2013). The N's and O's of Drosophila glycoprotein glycobiology.  Glycoconjugate J. 30(1): 57--66.
FlyBase ID
FBrf0220749
Publication Type
Review
Abstract

The past 25 years have seen significant advances in understanding the diversity and functions of glycoprotein glycans in Drosophila melanogaster. Genetic screens have captured mutations that reveal important biological activities modulated by glycans, including protein folding and trafficking, as well as cell signaling, tissue morphogenesis, fertility, and viability. Many of these glycan functions have parallels in vertebrate development and disease, providing increasing opportunities to dissect pathologic mechanisms using Drosophila genetics. Advances in the sensitivity of structural analytic techniques have allowed the glycan profiles of wild-type and mutant tissues to be assessed, revealing novel glycan structures that may be functionally analogous to vertebrate glycans. This review describes a selected set of recent advances in understanding the functions of N-linked and O-linked (non-glycosaminoglycan) glycoprotein glycans in Drosophila with emphasis on their relatedness to vertebrate organisms.

PubMed ID
PubMed Central ID
PMC3548036 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Glycoconjugate J.
    Title
    Glycoconjugate Journal
    Publication Year
    1984-
    ISBN/ISSN
    0282-0080
    Data From Reference
    Genes (13)