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Citation
Ferrandon, D. (2013). The complementary facets of epithelial host defenses in the genetic model organism Drosophila melanogaster: from resistance to resilience.  Curr. Opin. Immunol. 25(1): 59--70.
FlyBase ID
FBrf0220910
Publication Type
Review
Abstract
Significant advances have been made in our understanding of the host defense against microbial infections taking place at frontier epithelia of Drosophila flies. Immune deficiency (IMD), the major NF-κB immune response pathway induced in these epithelia, displays remarkable adaptations in its activation and regulation in the respiratory and digestive tract. The host defense against ingested pathogens is not limited to resistance, that is, the immune response. It also involves resilience, the capacity of the host to endure and repair damages inflicted by pathogens or the host's own immune response. For instance, enterocytes damaged by pathogens, the microbiota of aging flies, or host-derived reactive oxygen species (ROS), are replaced under the control of multiple pathways by the compensatory proliferation of intestinal stem cells (ISCs).
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Curr. Opin. Immunol.
    Title
    Current Opinion in Immunology
    Publication Year
    1988-
    ISBN/ISSN
    0952-7915
    Data From Reference