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Citation
Durdevic, Z., Hanna, K., Gold, B., Pollex, T., Cherry, S., Lyko, F., Schaefer, M. (2013). Efficient RNA virus control in Drosophila requires the RNA methyltransferase Dnmt2.  EMBO Rep. 14(3): 269--275.
FlyBase ID
FBrf0220943
Publication Type
Research paper
Abstract

Drosophila use small-interfering RNA mechanisms to limit the amplification of viral genomes. However, it is unclear how small RNA interference components recognize and separate viral from cellular RNA. Dnmt2 enzymes are highly conserved RNA methyltransferases with substrate specificity towards cellular tRNAs. We report here that Dnmt2 is required for efficient innate immune responses in Drosophila. Dnmt2 mutant flies accumulate increasing levels of Drosophila C virus and show activated innate immune responses. Binding of Dnmt2 to DCV RNA suggests that Dnmt2 contributes to virus control directly, possibly by RNA methylation. These observations demonstrate a role for Dnmt2 in antiviral defence.

PubMed ID
PubMed Central ID
PMC3589093 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Alleles (8)
    Genes (28)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (5)