Open Close
Reference
Citation
Aoki, T., Sarkeshik, A., Yates, J., Schedl, P. (2012). Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex.  eLife 1(): e00171.
FlyBase ID
FBrf0221291
Publication Type
Research paper
Abstract
Chromatin boundaries subdivide eukaryotic chromosomes into functionally autonomous domains of genetic activity. This subdivision insulates genes and/or regulatory elements within a domain from promiscuous interactions with nearby domains. While it was previously assumed that the chromosomal domain landscape is fixed, there is now growing evidence that the landscape may be subject to tissue and stage specific regulation. Here we report the isolation and characterization of a novel developmentally restricted boundary factor, Elba. We show that Elba is an unusual hetero-tripartite protein complex that requires all three proteins for DNA binding and insulator activity.DOI:http://dx.doi.org/10.7554/eLife.00171.001.
PubMed ID
PubMed Central ID
PMC3510454 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (1)
    Gene Groups (1)
    Genes (24)
    Physical Interactions (3)
    Transgenic Constructs (2)