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Citation
Alekseyenko, A.A., Ellison, C.E., Gorchakov, A.A., Zhou, Q., Kaiser, V.B., Toda, N., Walton, Z., Peng, S., Park, P.J., Bachtrog, D., Kuroda, M.I. (2013). Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila.  Genes Dev. 27(8): 853--858.
FlyBase ID
FBrf0221475
Publication Type
Research paper
Abstract
Dosage compensation has arisen in response to the evolution of distinct male (XY) and female (XX) karyotypes. In Drosophila melanogaster, the MSL complex increases male X transcription approximately twofold. X-specific targeting is thought to occur through sequence-dependent binding to chromatin entry sites (CESs), followed by spreading in cis to active genes. We tested this model by asking how newly evolving sex chromosome arms in Drosophila miranda acquired dosage compensation. We found evidence for the creation of new CESs, with the analogous sequence and spacing as in D. melanogaster, providing strong support for the spreading model in the establishment of dosage compensation.
PubMed ID
PubMed Central ID
PMC3650223 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genes Dev.
    Title
    Genes & Development
    Publication Year
    1987-
    ISBN/ISSN
    0890-9369
    Data From Reference
    Alleles (3)
    Genes (6)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (6)