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Citation
Sopko, R., Perrimon, N. (2013). Receptor tyrosine kinases in Drosophila development.  Cold Spring Harbor Perspect. Biol. 5(6): .
FlyBase ID
FBrf0221727
Publication Type
Review
Abstract

Tyrosine phosphorylation plays a significant role in a wide range of cellular processes. The Drosophila genome encodes more than 20 receptor tyrosine kinases and extensive studies in the past 20 years have illustrated their diverse roles and complex signaling mechanisms. Although some receptor tyrosine kinases have highly specific functions, others strikingly are used in rather ubiquitous manners. Receptor tyrosine kinases regulate a broad expanse of processes, ranging from cell survival and proliferation to differentiation and patterning. Remarkably, different receptor tyrosine kinases share many of the same effectors and their hierarchical organization is retained in disparate biological contexts. In this comprehensive review, we summarize what is known regarding each receptor tyrosine kinase during Drosophila development. Astonishingly, very little is known for approximately half of all Drosophila receptor tyrosine kinases.

PubMed ID
PubMed Central ID
PMC3660834 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cold Spring Harbor Perspect. Biol.
    Title
    Cold Spring Harbor perspectives in biology
    ISBN/ISSN
    1943-0264
    Data From Reference