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Citation
Fan, P., Manoli, D.S., Ahmed, O.M., Chen, Y., Agarwal, N., Kwong, S., Cai, A.G., Neitz, J., Renslo, A., Baker, B.S., Shah, N.M. (2013). Genetic and Neural Mechanisms that Inhibit Drosophila from Mating with Other Species.  Cell 154(1): 89--102.
FlyBase ID
FBrf0221991
Publication Type
Research paper
Abstract

Genetically hard-wired neural mechanisms must enforce behavioral reproductive isolation because interspecies courtship is rare even in sexually naïve animals of most species. We find that the chemoreceptor Gr32a inhibits male D. melanogaster from courting diverse fruit fly species. Gr32a recognizes nonvolatile aversive cues present on these reproductively dead-end targets, and activity of Gr32a neurons is necessary and sufficient to inhibit interspecies courtship. Male-specific Fruitless (Fru(M)), a master regulator of courtship, also inhibits interspecies courtship. Gr32a and Fru(M) are not coexpressed, but Fru(M) neurons contact Gr32a neurons, suggesting that these genes influence a shared neural circuit that inhibits interspecies courtship. Gr32a and Fru(M) also suppress within-species intermale courtship, but we show that distinct mechanisms preclude sexual displays toward conspecific males and other species. Although this chemosensory pathway does not inhibit interspecies mating in D. melanogaster females, similar mechanisms appear to inhibit this behavior in many other male drosophilids.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC3823234 (PMC) (EuropePMC)
Related Publication(s)
Note

Interspecies sex and taste.
Koh and Carlson, 2013, Cell 154(1): 20--21 [FBrf0222656]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference