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Citation
Moy, R.H., Cherry, S. (2013). Antimicrobial autophagy: a conserved innate immune response in Drosophila.  J. Innate Immun. 5(5): 444--455.
FlyBase ID
FBrf0222199
Publication Type
Review
Abstract
Autophagy is a highly conserved degradative pathway that has rapidly emerged as a critical component of immunity and host defense. Studies have implicated autophagy genes in restricting the replication of a diverse array of pathogens, including bacteria, viruses and protozoans. However, in most cases, the in vivo role of antimicrobial autophagy against pathogens has been undefined. Drosophila provides a genetically tractable model system that can be easily adapted to study autophagy in innate immunity, and recent studies in flies have demonstrated that autophagy is an essential antimicrobial response against bacteria and viruses in vivo. These findings reveal striking conservation of antimicrobial autophagy between flies and mammals, and in particular, the role of pathogen-associated pattern recognition in triggering this response. This review discusses our current understanding of antimicrobial autophagy in Drosophila and its potential relevance to human immunity.
PubMed ID
PubMed Central ID
PMC3799998 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Innate Immun.
    Title
    Journal of innate immunity
    ISBN/ISSN
    1662-811X 1662-8128
    Data From Reference