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Citation
Mbodj, A., Junion, G., Brun, C., Furlong, E.E., Thieffry, D. (2013). Logical modelling of Drosophila signalling pathways.  Mol. Biosyst. 9(9): 2248--2258.
FlyBase ID
FBrf0222237
Publication Type
Research paper
Abstract
A limited number of signalling pathways are involved in the specification of cell fate during the development of all animals. Several of these pathways were originally identified in Drosophila. To clarify their roles, and possible cross-talk, we have built a logical model for the nine key signalling pathways recurrently used in metazoan development. In each case, we considered the associated ligands, receptors, signal transducers, modulators, and transcription factors reported in the literature. Implemented using the logical modelling software GINsim, the resulting models qualitatively recapitulate the main characteristics of each pathway, in wild type as well as in various mutant situations (e.g. loss-of-function or gain-of-function). These models constitute pluggable modules that can be used to assemble comprehensive models of complex developmental processes. Moreover, these models of Drosophila pathways could serve as scaffolds for more complicated models of orthologous mammalian pathways. Comprehensive model annotations and GINsim files are provided for each of the nine considered pathways.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Mol. Biosyst.
    Title
    Molecular bioSystems
    Publication Year
    2005--
    ISBN/ISSN
    1742-206X 1742-2051
    Data From Reference