Open Close
Reference
Citation
Harvey, R., Schuster, E., Jennings, B.H. (2013). Pleiohomeotic interacts with the core transcription elongation factor spt5 to regulate gene expression in Drosophila.  PLoS ONE 8(7): e70184.
FlyBase ID
FBrf0222269
Publication Type
Research paper
Abstract

The early elongation checkpoint regulated by Positive Transcription Elongation Factor b (P-TEFb) is a critical control point for the expression of many genes. Spt5 interacts directly with RNA polymerase II and has an essential role in establishing this checkpoint, and also for further transcript elongation. Here we demonstrate that Drosophila Spt5 interacts both physically and genetically with the Polycomb Group (PcG) protein Pleiohomeotic (Pho), and the majority of Pho binding sites overlap with Spt5 binding sites across the genome in S2 cells. Our results indicate that Pho can interact with Spt5 to regulate transcription elongation in a gene specific manner.

PubMed ID
PubMed Central ID
PMC3718797 (PMC) (EuropePMC)
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference
    Genes (8)
    Physical Interactions (4)
    Cell Lines (1)