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Citation
Iovino, N., Ciabrelli, F., Cavalli, G. (2013). PRC2 Controls Drosophila Oocyte Cell Fate by Repressing Cell Cycle Genes.  Dev. Cell 26(4): 431--439.
FlyBase ID
FBrf0222535
Publication Type
Research paper
Abstract
The oocyte is a unique cell type that undergoes extensive chromosome changes on its way to fertilization, but the chromatin determinants of its fate are unknown. Here, we show that Polycomb group (PcG) proteins of the Polycomb repressive complex 2 (PRC2) determine the fate of the oocyte in Drosophila. Mutation of the enzymatic PRC2 subunit Enhancer of zeste (E(z)) in the germline abolishes spatial and temporal control of the cell cycle and induces sterility via transdetermination of the oocyte into a nurse-like cell. This fate switch depends on loss of silencing of two PRC2 target genes, Cyclin E and the cyclin-dependent kinase inhibitor dacapo. By contrast, the PRC1 component Polycomb (Pc) plays no role in this process. Our results demonstrate that PRC2 plays an exquisite role in the determination of the oocyte fate by preventing its switching into an endoreplicative program.
Graphical Abstract
Obtained with permission from Cell Press.
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PubMed Central ID
Related Publication(s)
Note
PRC2 Goes Solo in the Drosophila Female Germline.
Kassis and Lilly, 2013, Dev. Cell 26(4): 329--330 [FBrf0222514]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Alleles (6)
    Genes (12)
    Transgenic Constructs (1)