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Citation
Bausek, N. (2013). JAK-STAT signaling in stem cells and their niches in Drosophila.  JAKSTAT 2(3): e25686.
FlyBase ID
FBrf0222821
Publication Type
Review
Abstract

JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules.

PubMed ID
PubMed Central ID
PMC3772118 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    JAKSTAT
    Title
    JAK-STAT
    ISBN/ISSN
    2162-3988 2162-3996
    Data From Reference