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Citation
Tipping, M., Perrimon, N. (2014). Drosophila as a model for context-dependent tumorigenesis.  J. Cell. Physiol. 229(1): 27--33.
FlyBase ID
FBrf0222824
Publication Type
Review
Abstract

Drosophila can exhibit classic hallmarks of cancer, such as evasion of apoptosis, sustained proliferation, metastasis, prolonged survival, genome instability, and metabolic reprogramming, when cancer-related genes are perturbed. In the last two decades, studies in flies have identified several tumor suppressor and oncogenes. However, the greatest strength of the fly lies in its ability to model cancer hallmarks in a variety of tissue types, which enables the study of context-dependent tumorigenesis. We review the organs and tissues that have been used to model tumor formation, and propose new strategies to maximize the potential of Drosophila in cancer research.

PubMed ID
PubMed Central ID
PMC4034382 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell. Physiol.
    Title
    Journal of Cellular Physiology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9541
    Data From Reference