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Citation
Silver-Morse, L., Li, W.X. (2013). JAK-STAT in heterochromatin and genome stability.  JAKSTAT 2(3): e26090.
FlyBase ID
FBrf0222843
Publication Type
Review
Abstract

The canonical JAK-STAT signaling pathway transmits signals from the cell membrane to the nucleus, to regulate transcription of particular genes involved in development and many other physiological processes. It has been shown in Drosophila that JAK and STAT also function in a non-canonical mode, to regulate heterochromatin. This review discusses the non-canonical functioning of JAK and STAT, and its effects on biological processes. Decreased levels of activated JAK and increased levels of unphosphorylated STAT generate higher levels of heterochromatin. These higher heterochromatin levels result in suppression of hematopoietic tumor-like masses, increased resistance to DNA damage, and longer lifespan.

PubMed ID
PubMed Central ID
PMC3772121 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    JAKSTAT
    Title
    JAK-STAT
    ISBN/ISSN
    2162-3988 2162-3996
    Data From Reference