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Citation
Zoranovic, T., Grmai, L., Bach, E.A. (2013). Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.  JAKSTAT 2(3): e25408.
FlyBase ID
FBrf0222848
Publication Type
Review
Abstract

The JAK-STAT pathway is a key regulator of tissue size in Drosophila melanogaster. Here we provide an overview of its roles in processes that regulate the size of Drosophila imaginal discs, epithelia of diploid cells that proliferate and acquire specific fates in the larvae and that become functional in the adult. Drosophila has a single JAK and a single STAT gene, which has facilitated genetic dissection of this pathway. Moreover, the sophisticated genetic tools available in flies for clonal growth assays have made Drosophila an ideal organism in which to dissect the multiple roles of the JAK-STAT pathway in growth control. Studies in flies have revealed JAK-STAT pathway activity as a central node for diverse signals that control proliferation and mass accumulation. In addition, recent work has establish a new role for the pathway in cell competition, a process thought to be akin to the early stages of transformation in which more robust cells kill and take the place of less robust ones.

PubMed ID
PubMed Central ID
PMC3772117 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    JAKSTAT
    Title
    JAK-STAT
    ISBN/ISSN
    2162-3988 2162-3996
    Data From Reference