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Meister, G. (2013). Argonaute proteins: functional insights and emerging roles.  Nat. Rev. Genet. 14(7): 447--459.
FlyBase ID
FBrf0223046
Publication Type
Review
Abstract
Small-RNA-guided gene regulation has emerged as one of the fundamental principles in cell function, and the major protein players in this process are members of the Argonaute protein family. Argonaute proteins are highly specialized binding modules that accommodate the small RNA component - such as microRNAs (miRNAs), short interfering RNAs (siRNAs) or PIWI-associated RNAs (piRNAs) - and coordinate downstream gene-silencing events by interacting with other protein factors. Recent work has made progress in our understanding of classical Argonaute-mediated gene-silencing principles, such as the effects on mRNA translation and decay, but has also implicated Argonaute proteins in several other cellular processes, such as transcriptional regulation and splicing.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Rev. Genet.
    Title
    Nature Reviews. Genetics
    Publication Year
    2000-
    ISBN/ISSN
    1471-0056 1471-0064
    Data From Reference