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Citation
Péan, C.B., Dionne, M.S. (2014). Intracellular infections in Drosophila melanogaster: Host defense and mechanisms of pathogenesis.  Dev. Comp. Immunol. 42(1): 57--66.
FlyBase ID
FBrf0223123
Publication Type
Review
Abstract

The fruit-fly Drosophila melanogaster has emerged as a powerful model to study innate immunity against intracellular pathogens. To combat infection, the fly relies on multiple lines of defense, many of which are shared with mammals and arthropod vectors of human diseases. In addition to conserved immune pathways, the ease of performing sophisticated genetic screens has allowed the identification of novel host immune factors and novel pathogen virulence factors. Recently, some groups have exploited this to simultaneously analyze the host and pathogen genetics of intracellular infection. This review aims to unravel the Drosophila immune response against intracellular pathogens, highlighting recent discoveries.

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Comp. Immunol.
    Title
    Developmental and Comparative Immunology
    Publication Year
    1977-
    ISBN/ISSN
    0145-305X
    Data From Reference