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Citation
Keebaugh, E.S., Schlenke, T.A. (2014). Insights from natural host-parasite interactions: The Drosophila model.  Dev. Comp. Immunol. 42(1): 111--123.
FlyBase ID
FBrf0223129
Publication Type
Review
Abstract
Immune responses against opportunistic pathogens have been extensively studied in Drosophila, leading to a detailed map of the genetics behind innate immunity networks including the Toll, Imd, Jak-Stat, and JNK pathways. However, immune mechanisms of other organisms, such as plants, have primarily been investigated using natural pathogens. It was the use of natural pathogens in plant research that revealed the plant R-Avr system, a specialized immune response derived from antagonistic coevolution between plant immune proteins and their natural pathogens' virulence proteins. Thus, we recommend that researchers begin to use natural Drosophila pathogens to identify novel immune strategies that may have arisen through antagonistic coevolution with common natural pathogens. In this review, we address the benefits of using natural pathogens in research, describe the known natural pathogens of Drosophila, and discuss the future prospects for research on natural pathogens of Drosophila.
PubMed ID
PubMed Central ID
PMC3808516 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Comp. Immunol.
    Title
    Developmental and Comparative Immunology
    Publication Year
    1977-
    ISBN/ISSN
    0145-305X
    Data From Reference