Open Close
Cameron, S., Chang, W.T., Chen, Y., Zhou, Y., Taran, S., Rao, Y. (2013). Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein borderless.  J. Neurosci. 33(44): 17413--17421.
FlyBase ID
Publication Type
Research paper

Establishment of synaptic connections in the neuropils of the developing nervous system requires the coordination of specific neurite-neurite interactions (i.e., axon-axon, dendrite-dendrite and axon-dendrite interactions). The molecular mechanisms underlying coordination of neurite-neurite interactions for circuit assembly are incompletely understood. In this report, we identify a novel Ig superfamily transmembrane protein that we named Borderless (Bdl), as a novel regulator of neurite-neurite interactions in Drosophila. Bdl induces homotypic cell-cell adhesion in vitro and mediates neurite-neurite interactions in the developing visual system. Bdl interacts physically and genetically with the Ig transmembrane protein Turtle, a key regulator of axonal tiling. Our results also show that the receptor tyrosine phosphatase leukocyte common antigen-related protein (LAR) negatively regulates Bdl to control synaptic-layer selection. We propose that precise regulation of Bdl action coordinates neurite-neurite interactions for circuit formation in Drosophila.

PubMed ID
PubMed Central ID
PMC6618372 (PMC) (EuropePMC)
Associated Information
Associated Files
Other Information
Secondary IDs
    Language of Publication
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    J. Neurosci.
    Journal of Neuroscience
    Publication Year
    0270-6474 1529-2401
    Data From Reference
    Aberrations (1)
    Alleles (19)
    Genes (10)
    Physical Interactions (3)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (7)
    Transgenic Constructs (10)