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Citation
Cameron, S., Chang, W.T., Chen, Y., Zhou, Y., Taran, S., Rao, Y. (2013). Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein borderless.  J. Neurosci. 33(44): 17413--17421.
FlyBase ID
FBrf0223190
Publication Type
Research paper
Abstract

Establishment of synaptic connections in the neuropils of the developing nervous system requires the coordination of specific neurite-neurite interactions (i.e., axon-axon, dendrite-dendrite and axon-dendrite interactions). The molecular mechanisms underlying coordination of neurite-neurite interactions for circuit assembly are incompletely understood. In this report, we identify a novel Ig superfamily transmembrane protein that we named Borderless (Bdl), as a novel regulator of neurite-neurite interactions in Drosophila. Bdl induces homotypic cell-cell adhesion in vitro and mediates neurite-neurite interactions in the developing visual system. Bdl interacts physically and genetically with the Ig transmembrane protein Turtle, a key regulator of axonal tiling. Our results also show that the receptor tyrosine phosphatase leukocyte common antigen-related protein (LAR) negatively regulates Bdl to control synaptic-layer selection. We propose that precise regulation of Bdl action coordinates neurite-neurite interactions for circuit formation in Drosophila.

PubMed ID
PubMed Central ID
PMC6618372 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Neurosci.
    Title
    Journal of Neuroscience
    Publication Year
    1981-
    ISBN/ISSN
    0270-6474 1529-2401
    Data From Reference
    Aberrations (1)
    Alleles (19)
    Genes (10)
    Physical Interactions (3)
    Cell Lines (1)
    Natural transposons (1)
    Insertions (4)
    Experimental Tools (7)
    Transgenic Constructs (10)