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Citation
Chang, T.K., Shravage, B.V., Hayes, S.D., Powers, C.M., Simin, R.T., Wade Harper, J., Baehrecke, E.H. (2013). Uba1 functions in Atg7- and Atg3-independent autophagy.  Nat. Cell Biol. 15(9): 1067--1078.
FlyBase ID
FBrf0223303
Publication Type
Research paper
Abstract

Autophagy is a conserved process that delivers components of the cytoplasm to lysosomes for degradation. The E1 and E2 enzymes encoded by Atg7 and Atg3 are thought to be essential for autophagy involving the ubiquitin-like protein Atg8. Here, we describe an Atg7- and Atg3-independent autophagy pathway that facilitates programmed reduction of cell size during intestine cell death. Although multiple components of the core autophagy pathways, including Atg8, are required for autophagy and cells to shrink in the midgut of the intestine, loss of either Atg7 or Atg3 function does not influence these cellular processes. Rather, Uba1, the E1 enzyme used in ubiquitylation, is required for autophagy and reduction of cell size. Our data reveal that distinct autophagy programs are used by different cells within an animal, and disclose an unappreciated role for ubiquitin activation in autophagy.

PubMed ID
PubMed Central ID
PMC3762904 (PMC) (EuropePMC)
Related Publication(s)
Note

Autophagy: Atg independence in the midgut.
Wrighton, 2013, Nat. Rev. Mol. Cell Biol. 14(9): 546 [FBrf0223293]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nat. Cell Biol.
    Title
    Nature Cell Biology
    Publication Year
    1999-
    ISBN/ISSN
    1465-7392 1476-4679
    Data From Reference