Open Close
Reference
Citation
Thomae, A.W., Schade, G.O., Padeken, J., Borath, M., Vetter, I., Kremmer, E., Heun, P., Imhof, A. (2013). A pair of centromeric proteins mediates reproductive isolation in Drosophila species.  Dev. Cell 27(4): 412--424.
FlyBase ID
FBrf0223436
Publication Type
Research paper
Abstract
Speciation involves the reproductive isolation of natural populations due to the sterility or lethality of their hybrids. However, the molecular basis of hybrid lethality and the evolutionary driving forces that provoke it remain largely elusive. The hybrid male rescue (Hmr) and the lethal hybrid rescue (Lhr) genes serve as a model to study speciation in Drosophilids because their interaction causes lethality in male hybrid offspring. Here, we show that HMR and LHR form a centromeric complex necessary for proper chromosome segregation. We find that the Hmr expression level is substantially higher in Drosophila melanogaster, whereas Lhr expression levels are increased in Drosophila simulans. The resulting elevated amount of HMR/LHR complex in hybrids results in an extensive mislocalization of the complex, an interference with the regulation of transposable elements, and an impairment of cell proliferation. Our findings provide evidence for a major role of centromere divergence in the generation of biodiversity.
Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
Related Publication(s)
Note
Speciation mediated by centromeres.
Fukagawa, 2013, Dev. Cell 27(4): 367--368 [FBrf0223467]
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference