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Beckwith, E.J., Gorostiza, E.A., Berni, J., Rezával, C., Pérez-Santángelo, A., Nadra, A.D., Ceriani, M.F. (2013). Circadian Period Integrates Network Information Through Activation of the BMP Signaling Pathway.  PLoS Biol. 11(12): e1001733.
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Research paper

Living organisms use biological clocks to maintain their internal temporal order and anticipate daily environmental changes. In Drosophila, circadian regulation of locomotor behavior is controlled by ∼150 neurons; among them, neurons expressing the PIGMENT DISPERSING FACTOR (PDF) set the period of locomotor behavior under free-running conditions. To date, it remains unclear how individual circadian clusters integrate their activity to assemble a distinctive behavioral output. Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult brain. Acute deregulation of BMP signaling causes period lengthening through regulation of dClock transcription, providing evidence for a novel function of this pathway in the adult brain. We propose that coherence in the circadian network arises from integration in PDF neurons of both the pace of the cell-autonomous molecular clock and information derived from circadian-relevant neurons through release of BMP ligands.

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PMC3858370 (PMC) (EuropePMC)
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    Publication Type
    PLoS Biol.
    PLoS Biology
    Publication Year
    1545-7885 1544-9173
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