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Citation
Banreti, A., Hudry, B., Sass, M., Saurin, A.J., Graba, Y. (2014). Hox proteins mediate developmental and environmental control of autophagy.  Dev. Cell 28(1): 56--69.
FlyBase ID
FBrf0223806
Publication Type
Research paper
Abstract
Hox genes encode evolutionarily conserved transcription factors, providing positional information used for differential morphogenesis along the anteroposterior axis. Here, we show that Drosophila Hox proteins are potent repressors of the autophagic process. In inhibiting autophagy, Hox proteins display no apparent paralog specificity and do not provide positional information. Instead, they impose temporality on developmental autophagy and act as effectors of environmental signals in starvation-induced autophagy. Further characterization establishes that temporality is controlled by Pontin, a facultative component of the Brahma chromatin remodeling complex, and that Hox proteins impact on autophagy by repressing the expression of core components of the autophagy machinery. Finally, the potential of central and posterior mouse Hox proteins to inhibit autophagy in Drosophila and in vertebrate COS-7 cells indicates that regulation of autophagy is an evolutionary conserved feature of Hox proteins.
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Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
Related Publication(s)
Note
Ho(a)xing Autophagy to Regulate Development.
Campello and Cecconi, 2014, Dev. Cell 28(1): 3--4 [FBrf0223812]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference