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Citation
Asahina, K., Watanabe, K., Duistermars, B.J., Hoopfer, E., González, C.R., Eyjólfsdóttir, E.A., Perona, P., Anderson, D.J. (2014). Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila.  Cell 156(1-2): 221--235.
FlyBase ID
FBrf0223835
Publication Type
Research paper
Abstract
Males of most species are more aggressive than females, but the neural mechanisms underlying this dimorphism are not clear. Here, we identify a neuron and a gene that control the higher level of aggression characteristic of Drosophila melanogaster males. Males, but not females, contain a small cluster of FruM(+) neurons that express the neuropeptide tachykinin (Tk). Activation and silencing of these neurons increased and decreased, respectively, intermale aggression without affecting male-female courtship behavior. Mutations in both Tk and a candidate receptor, Takr86C, suppressed the effect of neuronal activation, whereas overexpression of Tk potentiated it. Tk neuron activation overcame reduced aggressiveness caused by eliminating a variety of sensory or contextual cues, suggesting that it promotes aggressive arousal or motivation. Tachykinin/Substance P has been implicated in aggression in mammals, including humans. Thus, the higher aggressiveness of Drosophila males reflects the sexually dimorphic expression of a neuropeptide that controls agonistic behaviors across phylogeny.
Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC3978814 (PMC) (EuropePMC)
Related Publication(s)
Note
Aggression: tachykinin is all the rage.
Pavlou et al., 2014, Curr. Biol. 24(6): R243--R244 [FBrf0224430]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Aberrations (1)
    Alleles (20)
    Genes (33)
    Natural transposons (2)
    Insertions (11)
    Experimental Tools (9)
    Transgenic Constructs (17)
    Transcripts (1)