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Citation
Salzmann, V., Inaba, M., Cheng, J., Yamashita, Y.M. (2013). Lineage tracing quantification reveals symmetric stem cell division in Drosophila male germline stem cells.  Cell. Mol. Bioeng. 6(4): 441--448.
FlyBase ID
FBrf0223894
Publication Type
Research paper
Abstract
In the homeostatic state, adult stem cells divide either symmetrically to increase the stem cell number to compensate stem cell loss, or asymmetrically to maintain the population while producing differentiated cells. We have investigated the mode of stem cell division in the testes of Drosophila melanogaster by lineage tracing and confirm the presence of symmetric stem cell division in this system. We found that the rate of symmetric division is limited to 1-2% of total germline stem cell (GSC) divisions, but it increases with expression of a cell adhesion molecule, E-cadherin, or a regulator of the actin cytoskeleton, Moesin, which may modulate adhesiveness of germ cells to the stem cell niche. Our results indicate that the decision regarding asymmetric vs. symmetric division is a dynamically regulated process that contributes to tissue homeostasis, responding to the needs of the tissue.
PubMed ID
PubMed Central ID
PMC3899098 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell. Mol. Bioeng.
    Title
    Cellular and molecular bioengineering
    ISBN/ISSN
    1865-5025 1865-5033
    Data From Reference
    Alleles (5)
    Genes (3)
    Natural transposons (1)
    Transgenic Constructs (5)