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Fulcher, N., Derboven, E., Valuchova, S., Riha, K. (2014). If the cap fits, wear it: an overview of telomeric structures over evolution.  Cell. Molec. Life Sci. 71(5): 847--865.
FlyBase ID
FBrf0224025
Publication Type
Review
Abstract

Genome organization into linear chromosomes likely represents an important evolutionary innovation that has permitted the development of the sexual life cycle; this process has consequently advanced nuclear expansion and increased complexity of eukaryotic genomes. Chromosome linearity, however, poses a major challenge to the internal cellular machinery. The need to efficiently recognize and repair DNA double-strand breaks that occur as a consequence of DNA damage presents a constant threat to native chromosome ends known as telomeres. In this review, we present a comparative survey of various solutions to the end protection problem, maintaining an emphasis on DNA structure. This begins with telomeric structures derived from a subset of prokaryotes, mitochondria, and viruses, and will progress into the typical telomere structure exhibited by higher organisms containing TTAGG-like tandem sequences. We next examine non-canonical telomeres from Drosophila melanogaster, which comprise arrays of retrotransposons. Finally, we discuss telomeric structures in evolution and possible switches between canonical and non-canonical solutions to chromosome end protection.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell. Molec. Life Sci.
    Title
    Cellular and molecular life sciences. CMLS
    Publication Year
    1997-
    ISBN/ISSN
    1420-682X
    Data From Reference
    Genes (4)
    Natural transposons (2)