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Citation
Markstein, M., Dettorre, S., Cho, J., Neumüller, R.A., Craig-Müller, S., Perrimon, N. (2014). Systematic screen of chemotherapeutics in Drosophila stem cell tumors.  Proc. Natl. Acad. Sci. U.S.A. 111(12): 4530--4535.
FlyBase ID
FBrf0224606
Publication Type
Research paper
Abstract

Here we report the development of an in vivo system to study the interaction of stem cells with drugs using a tumor model in the adult Drosophila intestine. Strikingly, we find that some Food and Drug Administration-approved chemotherapeutics that can inhibit the growth of Drosophila tumor stem cells can paradoxically promote the hyperproliferation of their wild-type counterparts. These results reveal an unanticipated side effect on stem cells that may contribute to tumor recurrence. We propose that the same side effect may occur in humans based on our finding that it is driven in Drosophila by the evolutionarily conserved Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway. An immediate implication of our findings is that supplementing traditional chemotherapeutics with anti-inflammatories may reduce tumor recurrence.

PubMed ID
PubMed Central ID
PMC3970492 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (5)
    Genes (5)
    Human Disease Models (2)
    Insertions (1)
    Transgenic Constructs (4)