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Citation
Chen, Q., Giedt, M., Tang, L., Harrison, D.A. (2014). Tools and methods for studying the Drosophila JAK/STAT pathway.  Methods 68(1): 160--172.
FlyBase ID
FBrf0225259
Publication Type
Review
Abstract

The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) signaling pathway is one of a limited number of signaling cascades that is extensively utilized for many developmental and homeostatic functions. The JAK/STAT pathway is evolutionarily conserved from insects to mammals, with homologous transduction machinery in each. Yet the mammalian pathway is composed of multiple members for each family of proteins, while flies have only a single homologue of most pathway components. This simplicity and the abundance of genetic, biochemical, and developmental tools make Drosophila an attractive model to investigate this important signaling pathway. This review provides a basic description of the Drosophila JAK/STAT cascade and summarizes currently available reagents and tools to study and manipulate the pathway.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Methods
    Title
    Methods [Supplement to Methods Enzymol.]
    Publication Year
    1990-
    ISBN/ISSN
    1046-2023
    Data From Reference
    Gene Groups (1)
    Genes (9)