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Citation
Wei, N., Serino, G., Deng, X.W. (2008). The COP9 signalosome: more than a protease.  Trends Biochem. Sci. 33(12): 592--600.
FlyBase ID
FBrf0225508
Publication Type
Review
Abstract
The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin-proteasome pathway. After two decades of research, we now know that the CSN is a multi-subunit protease that regulates the activity of cullin-RING ligase (CRL) families of ubiquitin E3 complexes. The CSN is rapidly emerging as a key player in the DNA-damage response, cell-cycle control and gene expression. The independent functions of CSN5 (also known as JAB1) add to the complexity of the CSN machinery. Here, we provide an updated view of the structure, functions and regulation of this protein complex.
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Compendium
    Abbreviation
    Trends Biochem. Sci.
    Title
    Trends in Biochemical Sciences
    Publication Year
    1976-
    ISBN/ISSN
    0167-7640 0968-0004
    Data From Reference
    Genes (5)