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Citation
Homem, C.C., Steinmann, V., Burkard, T.R., Jais, A., Esterbauer, H., Knoblich, J.A. (2014). Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.  Cell 158(4): 874--888.
FlyBase ID
FBrf0225887
Publication Type
Research paper
Abstract
Stem cells are highly abundant during early development but become a rare population in most adult organs. The molecular mechanisms causing stem cells to exit proliferation at a specific time are not well understood. Here, we show that changes in energy metabolism induced by the steroid hormone ecdysone and the Mediator initiate an irreversible cascade of events leading to cell-cycle exit in Drosophila neural stem cells. We show that the timely induction of oxidative phosphorylation and the mitochondrial respiratory chain are required in neuroblasts to uncouple the cell cycle from cell growth. This results in a progressive reduction in neuroblast cell size and ultimately in terminal differentiation. Brain tumor mutant neuroblasts fail to undergo this shrinkage process and continue to proliferate until adulthood. Our findings show that cell size control can be modified by systemic hormonal signaling and reveal a unique connection between metabolism and proliferation in stem cells.
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Obtained with permission from Cell Press.
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PubMed Central ID
Related Publication(s)
Note
Ch-ch-changes: hormones link stem cell differentiation with metabolic flux.
Buttitta and Lee, 2014, Cell Stem Cell 15(3): 262--264 [FBrf0226123]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference
    Alleles (50)
    Gene Groups (1)
    Genes (55)
    Physical Interactions (1)
    Natural transposons (1)
    Insertions (3)
    Experimental Tools (3)
    Transgenic Constructs (48)