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Reference
Citation
Koh, T.W., He, Z., Gorur-Shandilya, S., Menuz, K., Larter, N.K., Stewart, S., Carlson, J.R. (2014). The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors.  Neuron 83(4): 850--865.
FlyBase ID
FBrf0226011
Publication Type
Research paper
Abstract

Insects use taste to evaluate food, hosts, and mates. Drosophila has many "orphan" taste neurons that express no known taste receptors. The Ionotropic Receptor (IR) superfamily is best known for its role in olfaction, but virtually nothing is known about a clade of ∼35 members, the IR20a clade. Here, a comprehensive analysis of this clade reveals expression in all taste organs of the fly. Some members are expressed in orphan taste neurons, whereas others are coexpressed with bitter- or sugar-sensing Gustatory receptor (Gr) genes. Analysis of the closely related IR52c and IR52d genes reveals signatures of adaptive evolution, roles in male mating behavior, and sexually dimorphic expression in neurons of the male foreleg, which contacts females during courtship. These neurons are activated by conspecific females and contact a neural circuit for sexual behavior. Together, these results greatly expand the repertoire of candidate taste and pheromone receptors in the fly.

PubMed ID
PubMed Central ID
PMC4141888 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Ir-GAL4 insertions.
Carlson, 2015.4.22, Ir-GAL4 insertions. [FBrf0228234]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (2)
    Alleles (49)
    Genes (39)
    Sequence Features (3)
    Natural transposons (2)
    Insertions (4)
    Experimental Tools (5)
    Transgenic Constructs (47)
    Transcripts (18)