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Citation
Ito, S., Ueda, T., Ueno, A., Nakagawa, H., Taniguchi, H., Kayukawa, N., Miki, T. (2014). A genetic screen in Drosophila for regulators of human prostate cancer progression.  Biochem. Biophys. Res. Commun. 451(4): 548--555.
FlyBase ID
FBrf0226167
Publication Type
Research paper
Abstract

To uncover the mechanism by which human prostate cancer progresses, we performed a genetic screen for regulators of human prostate cancer progression using the Drosophila accessory gland, a functional homolog of the mammalian prostate. Cell growth and migration of secondary cells in the adult male accessory gland were found to be regulated by paired, N-cadherin, and E-cadherin, which are Drosophila homologues of regulators of human prostate cancer progression. Using this screening system, we also identified three genes that promoted growth and migration of secondary cells in the accessory gland. The human homologues of these candidate genes - MRGBP, CNPY2, and MEP1A - were found to be expressed in human prostate cancer model cells and to promote replication and invasiveness in these cells. These findings suggest that the development of the Drosophila accessory gland and human prostate cancer cell growth and invasion are partly regulated through a common mechanism. The screening system using the Drosophila accessory gland can be a useful tool for uncovering the mechanisms of human prostate cancer progression.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biochem. Biophys. Res. Commun.
    Title
    Biochemical and Biophysical Research Communications
    Publication Year
    1959-
    ISBN/ISSN
    0006-291X
    Data From Reference
    Alleles (30)
    Genes (31)
    Human Disease Models (6)
    Insertions (1)
    Transgenic Constructs (29)
    Transcripts (1)