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Citation
Ding, F., Gil, M.P., Franklin, M., Ferreira, J., Tatar, M., Helfand, S.L., Neretti, N. (2014). Transcriptional response to dietary restriction in Drosophila melanogaster.  J. Insect Physiol. 69(): 101--106.
FlyBase ID
FBrf0226330
Publication Type
Research paper
Abstract

Dietary restriction (DR) extends lifespan in a wide variety of organisms. Although several genes and pathways associated with this longevity response have been identified, the specific mechanism through which DR extends lifespan is not fully understood. We have recently developed a novel methodology to screen for transcriptional changes in response to acutely imposed DR upon adult Drosophila melanogaster and identified groups of genes that switch their transcriptional patterns from a normal diet pattern to a restricted diet pattern, or 'switching genes'. In this current report we extend our transcriptional data analysis with gene set enrichment analysis to generate a pathway-centered perspective. The pattern of temporal behavior in response to the diet switch is strikingly similar within and across pathways associated with mRNA processing and protein translation. Furthermore, most genes within these pathways display an initial spike in activity within 6-8h from the diet switch, followed by a coordinated, partial down-regulation after 24h. We propose this represents a stereotypical response to DR, which ultimately leads to a mild but widespread inhibition of transcriptional and translational activity. Inhibition of the protein synthesis pathway has been observed in DR in other studies and has been shown to extend lifespan in several model organisms.

PubMed ID
PubMed Central ID
PMC4177363 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Insect Physiol.
    Title
    Journal of Insect Physiology
    Publication Year
    1957-
    ISBN/ISSN
    0022-1910 1879-1611
    Data From Reference