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Citation
Limmer, S., Weiler, A., Volkenhoff, A., Babatz, F., Klämbt, C. (2014). The Drosophila blood-brain barrier: development and function of a glial endothelium.  Front. Neurosci. 8(): 365.
FlyBase ID
FBrf0226917
Publication Type
Review
Abstract
The efficacy of neuronal function requires a well-balanced extracellular ion homeostasis and a steady supply with nutrients and metabolites. Therefore, all organisms equipped with a complex nervous system developed a so-called blood-brain barrier, protecting it from an uncontrolled entry of solutes, metabolites or pathogens. In higher vertebrates, this diffusion barrier is established by polarized endothelial cells that form extensive tight junctions, whereas in lower vertebrates and invertebrates the blood-brain barrier is exclusively formed by glial cells. Here, we review the development and function of the glial blood-brain barrier of Drosophila melanogaster. In the Drosophila nervous system, at least seven morphologically distinct glial cell classes can be distinguished. Two of these glial classes form the blood-brain barrier. Perineurial glial cells participate in nutrient uptake and establish a first diffusion barrier. The subperineurial glial (SPG) cells form septate junctions, which block paracellular diffusion and thus seal the nervous system from the hemolymph. We summarize the molecular basis of septate junction formation and address the different transport systems expressed by the blood-brain barrier forming glial cells.
PubMed ID
PubMed Central ID
PMC4231875 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Front. Neurosci.
    Title
    Frontiers in neuroscience
    ISBN/ISSN
    1662-453X 1662-4548
    Data From Reference
    Gene Groups (15)
    Genes (134)