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Citation
Merino, M.M., Rhiner, C., Lopez-Gay, J.M., Buechel, D., Hauert, B., Moreno, E. (2015). Elimination of unfit cells maintains tissue health and prolongs lifespan.  Cell 160(3): 461--476.
FlyBase ID
FBrf0227415
Publication Type
Research paper
Abstract
Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on "fitness fingerprints" displayed on cell membranes, which allows direct fitness comparison among cells in Drosophila. Here, we study the physiological consequences of efficient cell selection for the whole organism. We find that fitness-based cell culling is naturally used to maintain tissue health, delay aging, and extend lifespan in Drosophila. We identify a gene, azot, which ensures the elimination of less fit cells. Lack of azot increases morphological malformations and susceptibility to random mutations and accelerates tissue degeneration. On the contrary, improving the efficiency of cell selection is beneficial for tissue health and extends lifespan.
Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4313366 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase
Primers used in construction of azot[KO] allele.
Merino and Moreno, 2015.4.11, Primers used in construction of azot[KO] allele. [FBrf0228390]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference