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Citation
Wang, L.H., Baker, N.E. (2015). Salvador-warts-hippo pathway in a developmental checkpoint monitoring helix-loop-helix proteins.  Dev. Cell 32(2): 191--202.
FlyBase ID
FBrf0227421
Publication Type
Research paper
Abstract

The E proteins and Id proteins are, respectively, the positive and negative heterodimer partners for the basic-helix-loop-helix protein family and as such contribute to a remarkably large number of cell-fate decisions. E proteins and Id proteins also function to inhibit or promote cell proliferation and cancer. Using a genetic modifier screen in Drosophila, we show that the Id protein Extramacrochaetae enables growth by suppressing activation of the Salvador-Warts-Hippo pathway of tumor suppressors, activation that requires transcriptional activation of the expanded gene by the E protein Daughterless. Daughterless protein binds to an intronic enhancer in the expanded gene, both activating the SWH pathway independently of the transmembrane protein Crumbs and bypassing the negative feedback regulation that targets the same expanded enhancer. Thus, the Salvador-Warts-Hippo pathway has a cell-autonomous function to prevent inappropriate differentiation due to transcription factor imbalance and monitors the intrinsic developmental status of progenitor cells, distinct from any responses to cell-cell interactions.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4308471 (PMC) (EuropePMC)
Related Publication(s)
Note

Hypo- or hyper-hippo: a balancing act with bHLH transcription factors.
Cook, 2015, Dev. Cell 32(2): 133--135 [FBrf0228201]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference
    Aberrations (95)
    Alleles (44)
    Genes (40)
    Natural transposons (1)
    Experimental Tools (5)
    Transgenic Constructs (18)