Open Close
Reference
Citation
Ward, A., Hong, W., Favaloro, V., Luo, L. (2015). Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit.  Neuron 85(5): 1013--1028.
FlyBase ID
FBrf0227741
Publication Type
Research paper
Abstract

Our understanding of the mechanisms that establish wiring specificity of complex neural circuits is far from complete. During Drosophila olfactory circuit assembly, axons of 50 olfactory receptor neuron (ORN) classes and dendrites of 50 projection neuron (PN) classes precisely target to 50 discrete glomeruli, forming parallel information-processing pathways. Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the targeting of specific classes of PN dendrites and ORN axons, respectively. The canonical ligands and downstream partners of Toll receptors in embryonic patterning and innate immunity are not required for the function of Toll-6/Toll-7 in wiring specificity, nor are their cytoplasmic domains. Interestingly, both Toll-6 and Toll-7 participate in synaptic partner matching between ORN axons and PN dendrites. Our investigations reveal that olfactory circuit assembly involves dynamic and long-range interactions between PN dendrites and ORN axons.

PubMed ID
PubMed Central ID
PMC4351475 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Clonality of Toll-6 and Toll-7 antibodies.
Ward A., 2015.10.7, Clonality of Toll-6 and Toll-7 antibodies. [FBrf0229760]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Aberrations (2)
    Alleles (35)
    Genes (22)
    Natural transposons (1)
    Insertions (14)
    Experimental Tools (7)
    Transgenic Constructs (17)
    Transcripts (5)