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Citation
Kim, J.H., Ren, Y., Ng, W.P., Li, S., Son, S., Kee, Y.S., Zhang, S., Zhang, G., Fletcher, D.A., Robinson, D.N., Chen, E.H. (2015). Mechanical tension drives cell membrane fusion.  Dev. Cell 32(5): 561--573.
FlyBase ID
FBrf0227785
Publication Type
Research paper
Abstract

Membrane fusion is an energy-consuming process that requires tight juxtaposition of two lipid bilayers. Little is known about how cells overcome energy barriers to bring their membranes together for fusion. Previously, we have shown that cell-cell fusion is an asymmetric process in which an "attacking" cell drills finger-like protrusions into the "receiving" cell to promote cell fusion. Here, we show that the receiving cell mounts a Myosin II (MyoII)-mediated mechanosensory response to its invasive fusion partner. MyoII acts as a mechanosensor, which directs its force-induced recruitment to the fusion site, and the mechanosensory response of MyoII is amplified by chemical signaling initiated by cell adhesion molecules. The accumulated MyoII, in turn, increases cortical tension and promotes fusion pore formation. We propose that the protrusive and resisting forces from fusion partners put the fusogenic synapse under high mechanical tension, which helps to overcome energy barriers for membrane apposition and drives cell membrane fusion.

Graphical Abstract
Obtained with permission from Cell Press.
PubMed ID
PubMed Central ID
PMC4357538 (PMC) (EuropePMC)
Related Publication(s)
Note

Myoblast fusion: playing hard to get.
Chernomordik and Kozlov, 2015, Dev. Cell 32(5): 529--530 [FBrf0227867]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Dev. Cell
    Title
    Developmental Cell
    Publication Year
    2001-
    ISBN/ISSN
    1534-5807 1878-1551
    Data From Reference