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Citation
Tsai, Y.C., Grimm, S., Chao, J.L., Wang, S.C., Hofmeyer, K., Shen, J., Eichinger, F., Michalopoulou, T., Yao, C.K., Chang, C.H., Lin, S.H., Sun, Y.H., Pflugfelder, G.O. (2015). Optomotor-Blind Negatively Regulates Drosophila Eye Development by Blocking Jak/STAT Signaling.  PLoS ONE 10(3): e0120236.
FlyBase ID
FBrf0227821
Publication Type
Research paper
Abstract

Organ formation requires a delicate balance of positive and negative regulators. In Drosophila eye development, wingless (wg) is expressed at the lateral margins of the eye disc and serves to block retinal development. The T-box gene optomotor-blind (omb) is expressed in a similar pattern and is regulated by Wg. Omb mediates part of Wg activity in blocking eye development. Omb exerts its function primarily by blocking cell proliferation. These effects occur predominantly in the ventral margin. Our results suggest that the primary effect of Omb is the blocking of Jak/STAT signaling by repressing transcription of upd which encodes the Jak receptor ligand Unpaired.

PubMed ID
PubMed Central ID
PMC4363906 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS ONE
    Title
    PLoS ONE
    Publication Year
    2006-
    ISBN/ISSN
    1932-6203
    Data From Reference