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Serbus, L.R., White, P.M., Silva, J.P., Rabe, A., Teixeira, L., Albertson, R., Sullivan, W. (2015). The impact of host diet on wolbachia titer in Drosophila.  PLoS Pathog. 11(3): e1004777.
FlyBase ID
FBrf0228004
Publication Type
Research paper
Abstract

While a number of studies have identified host factors that influence endosymbiont titer, little is known concerning environmental influences on titer. Here we examined nutrient impact on maternally transmitted Wolbachia endosymbionts in Drosophila. We demonstrate that Drosophila reared on sucrose- and yeast-enriched diets exhibit increased and reduced Wolbachia titers in oogenesis, respectively. The yeast-induced Wolbachia depletion is mediated in large part by the somatic TOR and insulin signaling pathways. Disrupting TORC1 with the small molecule rapamycin dramatically increases oocyte Wolbachia titer, whereas hyper-activating somatic TORC1 suppresses oocyte titer. Furthermore, genetic ablation of insulin-producing cells located in the Drosophila brain abolished the yeast impact on oocyte titer. Exposure to yeast-enriched diets altered Wolbachia nucleoid morphology in oogenesis. Furthermore, dietary yeast increased somatic Wolbachia titer overall, though not in the central nervous system. These findings highlight the interactions between Wolbachia and germline cells as strongly nutrient-sensitive, and implicate conserved host signaling pathways by which nutrients influence Wolbachia titer.

PubMed ID
PubMed Central ID
PMC4380406 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Correction: The Impact of Host Diet on Wolbachia Titer in Drosophila.
Serbus et al., 2015, PLoS Pathog. 11(5): e1004889 [FBrf0228372]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Pathog.
    Title
    PLoS Pathogens
    Publication Year
    2005-
    ISBN/ISSN
    1553-7366 1553-7374
    Data From Reference
    Genes (4)