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Citation
Baëza, M., Viala, S., Heim, M., Dard, A., Hudry, B., Duffraisse, M., Rogulja-Ortmann, A., Brun, C., Merabet, S. (2015). Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo.  eLife 4(): e06034.
FlyBase ID
FBrf0228100
Publication Type
Research paper
Abstract

Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although these interactions remain to be analysed in the context of endogenous Hox regulatory activities, our observations challenge the traditional role assigned to SLiMs and provide an alternative concept to explain how Hox interactome specificity could be achieved during the embryonic development.

PubMed ID
PubMed Central ID
PMC4392834 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Genes (40)
    Physical Interactions (156)
    Cell Lines (1)