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Citation
Arya, R., White, K. (2015). Cell death in development: Signaling pathways and core mechanisms.  Semin. Cell Dev. Biol. 39(): 12--19.
FlyBase ID
FBrf0228224
Publication Type
Review
Abstract
Programmed cell death eliminates unneeded and dangerous cells in a timely and effective manner during development. In this review, we examine the role cell death plays during development in worms, flies and mammals. We discuss signaling pathways that regulate developmental cell death, and describe how they communicate with the core cell death pathways. In most organisms, the majority of developmental cell death is seen in the nervous system. Therefore we focus on what is known about the regulation of developmental cell death in this tissue. Understanding how the cell death is regulated during development may provide insight into how this process can be manipulated in the treatment of disease.
PubMed ID
PubMed Central ID
PMC4410075 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Semin. Cell Dev. Biol.
    Title
    Seminars in cell and developmental biology
    Publication Year
    1996-
    ISBN/ISSN
    1084-9521
    Data From Reference