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Citation
Lucchesi, J.C., Kuroda, M.I. (2015). Dosage Compensation in Drosophila.  Cold Spring Harbor Perspect. Biol. 7(5): a019398.
FlyBase ID
FBrf0228243
Publication Type
Review
Abstract
Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X. Nucleation and sequence-independent spreading of the complex to active genes serves as a model for understanding the targeting and function of epigenetic chromatin-modifying complexes. Interestingly, two noncoding RNAs are key for MSL assembly and spreading to active genes along the length of the X chromosome.
PubMed ID
PubMed Central ID
PMC4448616 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cold Spring Harbor Perspect. Biol.
    Title
    Cold Spring Harbor perspectives in biology
    ISBN/ISSN
    1943-0264
    Data From Reference
    Gene Groups (1)
    Genes (16)