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Citation
Ghimire, S., Kim, M.S. (2015). Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila.  Biomol. Ther. (Seoul) 23(3): 290--295.
FlyBase ID
FBrf0228469
Publication Type
Research paper
Abstract

Aging is defined as a collective process that alters organism's functional capacity and appearance over the course of life. Apart from an increase in susceptibility to many diseases, aging affects the cellular system that is responsible for decoding painful stimuli. Yet, aging-associated molecular mechanisms of pain perception remains elusive. Using Drosophila, we showed a decrease in temperature tolerance and a reduction in high temperature thermal avoidance with aging. Locomotor activity assay demonstrated that the age-dependent changes in heat nociception did not stem from the general decline in muscular activity. However, we identified pain-related gene expression alteration with aging. We anticipate that our findings would help opening a new window onto developing the optimal pain treatment for the elderly.

PubMed ID
PubMed Central ID
PMC4428723 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Biomol. Ther. (Seoul)
    Title
    Biomolecules & therapeutics
    ISBN/ISSN
    1976-9148 2005-4483
    Data From Reference
    Genes (6)