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Citation
Su, T.T. (2015). Non-autonomous consequences of cell death and other perks of being metazoan.  AIMS Genet. 2(1): 54--69.
FlyBase ID
FBrf0228656
Publication Type
Review
Abstract

Drosophila melanogaster remains a foremost genetic model to study basic cell biological processes in the context of multi-cellular development. In such context, the behavior of one cell can influence another. Non-autonomous signaling among cells occurs throughout metazoan development and disease, and is too vast to be covered by a single review. I will focus here on non-autonomous signaling events that occur in response to cell death in the larval epithelia and affect the life-death decision of surviving cells. I will summarize the use of Drosophila to study cell death-induced proliferation, apoptosis-induced apoptosis, and apoptosis-induced survival signaling. Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology.

PubMed ID
PubMed Central ID
PMC4461274 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    AIMS Genet.
    Title
    AIMS genetics
    ISBN/ISSN
    2377-1143
    Data From Reference